The Synaptic Leap

 Role of the BACTEC radiometric method in the evaluation of patients with clinically probable tuberculous meningitisPanicker Jn et al.Annals of Indian Academy of Neurology 13 (2), (01 Apr 2010)info:doi/10.4103/0972-2327.64637Posted by sneha89 to BACTEC meningitis Tuberculosis on Wed Sep 01 2010 at 12:08 UTC | info | related

 BOVINE TUBERCULOSIS IN ETHIOPIAN WILDLIFER. Tschopp et al.Journal of Wildlife Diseases 46 (3), 753-62 (01 Jul 2010)Posted by madzoovet to Tuberculosis Ethiopia on Tue Aug 10 2010 at 12:10 UTC | info | related

 'Hidden' tuberculosis raises drug-resistance fears - on article in PLoS MedHidden tuberculosis raises drugresistance fearsAmy MaxmenNature News, (23 Jun 2010)info:doi/10.1038/news.2010.311New study doubles known rate of infection at a South African hospital ... Huge and hidden levels of tuberculosis discovered in a South African province devastated by HIV are increasing concerns about the prevalence of drug-resistant tuberculosis in Africa. As reported in PLoS Medicine1, when researchers examined newly deceased patients at Edendale hospital in the province of KwaZulu-Natal, they discovered that 50% were infected with the bacterium M. tuberculosis, the causal agent of tuberculosis, with 17% of the infected individuals carrying a multi-drug resistant (MDR) strain. Among those with TB, only 58% had been diagnosed and started on treatment before their death. A previous study had found that only 28% of patients admitted to the same hospital were diagnosed with active tuberculosis. In the new study, 96% of those positive for M. tuberculosis were also HIV positive, and the alarming prevalence of tuberculosis may reflect the situation in other low-income countries plagued by HIV. With weakened immunity, HIV-positive individuals are extremely vulnerable to other infections.Posted by NatureRevMicrobiol to Drug resistance tb Tuberculosis MDR on Fri Jun 25 2010 at 04:18 UTC | info | related

 India's tuberculosis genome project under fireK JayaramanNature News, (09 Jun 2010)info:doi/10.1038/news.2010.285Sequence annotated by students should be peer reviewed, say scientists ... India's Open Source Drug Discovery (OSDD) project has drawn criticism from geneticists for not publishing its first results in a peer-reviewed journal. Researchers have also dismissed as hype some of the claims made by the project's chief coordinator, Samir Brahmachari. Launched with much fanfare in September 2008 in the presence of Kapil Sibal, then India's science minister, the 1.5-billion-rupee (US$32-million) OSDD project aims to speed drug discovery — primarily against tuberculosis — by giving researchers an open platform for sharing their work through the Internet. But controversy has followed Brahmachari's highly publicized announcement on 11 April that the project has comprehensively mapped, compiled and verified the genome of Mycobacterium tuberculosis, the bacterium that causes tuberculosis. In particular, many researchers dispute Brahmachari's claim that the project has made the annotated genome publicly available "for the first time" — they note that other institutions, including the Wellcome Trust Sanger Institute in Hinxton, UK, and the Broad Institute in Cambridge, Massachusetts, already host publicly available annotated versions of the bacterium's genome.Posted by NatureRevMicrobiol to tb Tuberculosis genome genomes on Sat Jun 12 2010 at 15:20 UTC | info | related

 BBC News - Predictive blood test for TB 'a step closer' - on article in Naturewww.bbc.co.uknternational researchers say they have made a "significant step" towards a predictive blood test for tuberculosis. A DNA fingerprint in the blood shows promise in identifying which carriers of TB will go on to get symptoms and spread the infection. Such a test would allow earlier diagnosis and treatment of the lung disease, potentially saving many lives.Posted by NatureRevMicrobiol to tb treatment Tuberculosis diagnosis therapy on Tue Aug 24 2010 at 01:41 UTC | info | related

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 Identification and Management of Latent Tuberculosis Infection - May 15, 2009 - American Family Physicianwww.aafp.orglist who should be checked for latent TB.how interpret TST[mantoux].Posted by alwhiting to Tuberculosis on Sat Jun 26 2010 at 10:33 UTC | info | related

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 PLoS Medicine: The Prevalence and Drug Sensitivity of Tuberculosis among Patients Dying in Hospital in KwaZulu-Natal, South Africa: A Postmortem Studywww.plosmedicine.orgBackground. Tuberculosis is the leading cause of death in South Africa by death notification, but accurate diagnosis of tuberculosis is challenging in this setting of high HIV prevalence. We conducted limited autopsies on young adults dying in a single public hospital in the province of KwaZulu-Natal between October 2008 and August 2009 in order to estimate the magnitude of deaths attributable to tuberculosis. Methods and Findings. We studied a representative sample of 240 adult inpatients (aged 20–45 years) dying after admission to Edendale Hospital. Limited autopsies included collection of respiratory tract secretions and tissue by needle core biopsies of lung, liver, and spleen. Specimens were examined by fluorescent microscopy for acid-fast bacilli and cultured in liquid media; cultures positive for M. tuberculosis were tested for drug susceptibility to first- and second-line antibiotics. Ninety-four percent of our study cohort was HIV seropositive and 50% of decedents had culture-positive tuberculosis at the time of death. Fifty percent of the participants were on treatment for tuberculosis at the time of death and 58% of these treated individuals remained culture positive at the time of death. Of the 50% not receiving tuberculosis treatment, 42% were culture positive. Seventeen percent of all positive cultures were resistant to both isoniazid and rifampin (i.e., multidrug resistant); 16% of patients dying during the initiation phase of their first ever course of tuberculosis treatment were infected with multidrug-resistant bacilli. Conclusions. Our findings reveal the immense toll of tuberculosis among HIV-positive individuals in KwaZulu-Natal. The majority of decedents who remained culture positive despite receiving tuberculosis treatment were infected with pan-susceptible M. tuberculosis, suggesting that the diagnosis of tuberculosis was made too late to alter the fatal course of the infection. There is also a significant burden of undetected multidrug-resistant tuberculosis among HIV-coinfected individuals dying in this setting. New public health approaches that improve early diagnosis of tuberculosis and accelerate the initiation of treatment are urgently needed in this setting.Posted by NatureRevMicrobiol to Drug resistance tb Tuberculosis MDR on Fri Jun 25 2010 at 04:22 UTC | info | related

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 Timing of Antiretroviral Drugs during Tuberculosis TherapyDouglas Wilson et al.The New England Journal of Medicine 362 (22), 2137-9 (03 Jun 2010)info:doi/10.1056/NEJMc1003767Posted by mattprice to Tuberculosis HIV on Thu Jun 03 2010 at 07:45 UTC | info | related

 PLoS ONE: Ambulatory-Based Standardized Therapy for Multi-Drug Resistant Tuberculosis: Experience from Nepal, 2005–2006dx.plos.orgPosted by tbodmer to Nepal Drug resistance Tuberculosis MDR TB on Sat Jun 12 2010 at 09:23 UTC | info | related

 Tuberculosis expert to head US charity's African labLinda NordlingNature News, (26 May 2010)info:doi/10.1038/news.2010.264William Bishai talks about the logic of locating a Howard Hughes Medical Institute in Durban ... William Bishai, a tuberculosis specialist, was today named as the director of the first Howard Hughes Medical Institute (HHMI) research laboratory outside the United States. HHMI will invest US$70 million over ten years in the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) being built in Durban, South Africa. Bishai will take up the post in September. As part of a partnership with the University of KwaZulu-Natal in South Africa, the research institute will study HIV and tuberculosis, and the interaction between the two diseases. Tuberculosis is a major cause of death for people living with HIV and AIDS. Construction of the building is scheduled to start in September, and it is due to open in 2012. The institute is expected to house 110 staff, including nearly 50 researchers.Posted by NatureRevMicrobiol to tb Tuberculosis research on Thu May 27 2010 at 08:28 UTC | info | related

 An Epidemiological Approach To Tuberculosispresshound.comPosted by makemoneyon to Mycobacterium Tuberculosis on Wed Jun 09 2010 at 00:11 UTC | info | related

 African Mining May Be Driving TB Epidemic - NYTimes.com - on article in Am J Pub Healthwww.nytimes.comPoor living and working conditions for miners of gold, diamonds and other precious metals have contributed significantly to tuberculosis (TB) epidemics across Africa, scientists said on Tuesday. Researchers from Britain and the United States said their study suggested that crowded living and working conditions, dust in mines, and the spread of HIV mean Africa's mining industry may figure in up to 760,000 new cases of TB each year. Men travelling from afar to work in mines, such as from Botswana to South Africa, are at the greatest risk of getting TB.Posted by NatureRevMicrobiol to Africa Tuberculosis tb on Wed Jun 02 2010 at 05:02 UTC | info | related

 Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis : The Lancetwww.thelancet.comPosted by amilmon1 to conseguir Tuberculosis on Tue Jun 01 2010 at 20:43 UTC | info | related