blogs

26 Feb

Sulfonamides

Published by Matin

As I alluded to at the end of my previous entry, I've been working on a way to make sulfonamides of the arryl pyrrole series for the OSDD Malaria project.

 
 
 
 
 
 
Figure 1. Examples of sulfonamides that are currently being made for testing as anti-malarials.

02 Jan

Abridged Transcript of OSDD Open Meeting (17.12.12)

Published by Alice Williamson

Subject 

Results

+OSDD Malaria, @OSDDMalaria

Attendees:

Matthew Houghton Todd (MHT), University of Sydney, +Matthew Todd, @MatToddChem

Paul Willis (PW), Medicines for Malaria Venture, http://www.mmv.org/about-us/our-team/paul-willis

Murray N Robertson (MNR), University of Sydney, +Murray Robertson, @murrayfold

Alice E Williamson (AEW), University of Sydney, +Alice Williamson, @all_isee

12 Dec

Draft Agenda for OSDD Consultation:

Published by Alice Williamson

 
The next meeting will take place online at this location: Meeting Room 
At these times Monday 17th December 2012:
San Francisco 6 am 
New York 9 am 
London 2 pm 
Geneva 3 pm 
Delhi 7:30 pm 
Sydney 1 am (so on Tuesday 18th) 
 
Agenda Items: (being edited) 
 
1. Summary of current aryl pyrrole status and biological results
 

12 Dec

Pharmacophore Modelling Using The Aryl Pyrrole Data To Date.

Published by m.robertson

Subject 

Request for Help

I’ve recently been doing some pharmacophore modelling of some of the OSM and GSK compounds.  I was kindly given access to the Schrodinger Suit Software by Dai Hibbs in the Faculty of Pharmacy here at Sydney.  Unfortunately, my previous experience with the Schrodinger software is rather limited and I’ve never used the Phase application before.  Anyway, I set about getting used to the software again watching all the online tutorials and reading the manuals.  After getting used to the software a nice trend in the data was found and I set about tuning this model.  Unfortunately this is where I’

10 Dec

Advice Needed: Generation of Analogues in the Thienopyrimidine Series

Published by JimCronshaw

Seasons greetings all. This is the December 2012 update from my side of the Todd lab. I have finished my honours project and submitted my thesis to obtain Hons I - which is highly pleasing - and I'm back for a period of time to assist the Todd group and their antimalarial project. Specifically, I hope to generate a variety of analogues of the hit compound within the aminothienopyrimidine series (Figure 1)

 

05 Dec

Summary of the ArylPyrrole Data

Published by Alice Williamson

Here is a summary of the biological data obtained for the aryl pyrroles to date:

The team have been looking for patterns in the data ahead of the next consultation. The scheme below concisely displays the patterns that have been identified at this stage of the project. More detailed analysis including the structures and activities of all compounds that have been biologically evaluated can be found on the OSDD Malaria G+ page

30 Nov

First Set of Biological Results from the Third Round of Compounds

Published by Alice Williamson

 

The team set about synthesising targets SA - SJ and ordered the commercial compounds chosen at the consultation in July. In late September, the commercial compounds, plus some of the synthetic targets (and analogues) were sent away for biological evaluation.

27 Nov

Project Update

Published by Alice Williamson
Where is the project up to?

We've been busy working on the synthesis of the ten 'final' aryl pyrrole compounds chosen after the consultation in July. 

This post is a brief summary of the current project status to let people know what has been achieved and which compounds still need to be conquered.

 

So here we go:

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