Possible molecular targets for schisto research should be child pages off this one.
A recent paper suggests that thioredoxin glutathione reductase from S. mansoni is an interesting drug target for schisto, particularly given that PZQ was inactive against this target.
From a quick look at the paper it appears as though no crystal structure is available for the enzyme, but screening is required.
I wonder: is there anything the community can do here as a research project in virtual screening, given the data in the paper on compounds already tested?
Mat