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Biological Results for ATP Series from April 2013

Published by MatTodd on 1 May 2013 - 3:48am



Comments on Latest Biological Results - April 2013

Data may be viewed here.
General page for the whole aminothienopyrmidine series is here.

The content of this post is also viewable on a Google+ post.

Biological Data

Published by MatTodd on 1 May 2013 - 3:39am



Chid pages to this one focus on biological evaluation in the GSK ATP project - results and the response to the results.


The GSK Aminothienopyrimidine (ATP) Series

Published by MatTodd on 1 May 2013 - 3:38am



The second strand of the open source drug discovery for malaria project involves aminothienopyrimidines (ATPs). The wiki summary page contains the current To Do list. Child pages to this one refer to specific aspects of the project.

26 Feb


Published by Matin

As I alluded to at the end of my previous entry, I've been working on a way to make sulfonamides of the arryl pyrrole series for the OSDD Malaria project.

Figure 1. Examples of sulfonamides that are currently being made for testing as anti-malarials.

02 Jan

Abridged Transcript of OSDD Open Meeting (17.12.12)

Published by Alice Williamson



+OSDD Malaria, @OSDDMalaria


Matthew Houghton Todd (MHT), University of Sydney, +Matthew Todd, @MatToddChem

Paul Willis (PW), Medicines for Malaria Venture,

Murray N Robertson (MNR), University of Sydney, +Murray Robertson, @murrayfold

Alice E Williamson (AEW), University of Sydney, +Alice Williamson, @all_isee

Biological Results for Third Set of Compounds

Published by MatTodd on 15 December 2012 - 6:57am



A summary of the biological activities obtained for the third set of compounds in 2012 - those arising from the consultation for which synthetic and commercial compounds that were most wanted. See also some links for analysis of trends in the data.

First set (Oct 19th) Data, and these were discussed briefly in an online meeting.

12 Dec

Pharmacophore Modelling Using The Aryl Pyrrole Data To Date.

Published by m.robertson


Request for Help

I’ve recently been doing some pharmacophore modelling of some of the OSM and GSK compounds.  I was kindly given access to the Schrodinger Suit Software by Dai Hibbs in the Faculty of Pharmacy here at Sydney.  Unfortunately, my previous experience with the Schrodinger software is rather limited and I’ve never used the Phase application before.  Anyway, I set about getting used to the software again watching all the online tutorials and reading the manuals.  After getting used to the software a nice trend in the data was found and I set about tuning this model.  Unfortunately this is where I’