RSS Feed for Recent Posts http://www.thesynapticleap.org/rss/recent en Tuberculosis Research Community http://www.thesynapticleap.org/tb/community <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>Welcome, I'm <a title="Dr. Mitchell's Home Page" target="_self" href="http://faculty.salisbury.edu/~momitchell/">Miguel Mitchell</a>, the online leader for The Synaptic Leap tuberculosis research community. </p> <h3>Why Tuberculosis Is Important</h3> <p>Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb), infects approximately two billion people. The World Health Organization estimates that about two million people die each year from TB due to the lack of and inability to afford proper health care. Overcrowding and ill-nourishment of poor people living in large cities leads to ahigh incidence of the disease due to the ease at which the infection can be transferred. This contributes to the accelerated speed at which TB spreads in underdeveloped countries. There is also an alarming increase in cases of TB caused by multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), due in part to inadequate drug therapy as a result of incorrectly selected medications or suboptimal drug dosing. Thus, there is a need for new drugs targeting enzymes essential to mycobacterial survival. </p> <h2>Join Us and Login</h2> <p>As a guest on The Synaptic Leap, you can browse and look all you want.  You must <a title="login page for The Synaptic Leap" href="?q=login" target="_self">login</a> and create a user profile for yourself if you want to participate. Once you are logged in you may begin collaborating with other scientists world-wide and become a part of the collective intelligence trying to help improve the drugs available for schisto.  </p> <h2>Get Involved with an Open Research Project </h2> <p>See <a title="open research projects for tuberculosis" target="_self" href="?q=tb/projects">current projects</a> for a list of our active open research projects.  You may learn more about these projects and learn how you can participate.  Or, you may "add a child page" (see the link at the bottom) to initiate and describe your own open research project for tuberculosis.</p> </div></div></div> Wed, 16 Aug 2006 00:46:31 +0000 Miguel Mitchell 119 at http://www.thesynapticleap.org Development of Novel Antitubercular Drugs http://www.thesynapticleap.org/node/118 <div class="field field-name-taxonomy-vocabulary-3 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Community&nbsp;</h3> <span class="field-items"> <a href="/tb/posts">tuberculosis research community</a> </span> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p> </p> <p>This is a call for creating a tuberculosis research community.</p> <p><strong>Background</strong></p> <p>Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb), infects approximately two billion people. The World Health Organization estimates that about two million people die each year from TB due to the lack of and inability to afford proper health care.<sup>1</sup> Overcrowding and ill-nourishment of poor people living in large cities leads to a high incidence of the disease due to the ease at which the infection can be transferred.<sup>2</sup> This contributes to the accelerated speed at which TB spreads in underdeveloped countries. There is also an alarming increase in cases of TB caused by multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), due in part to inadequate drug therapy as a result of incorrectly selected medications or suboptimal drug dosing.<sup>3</sup> Thus, there is a need for new drugs targeting enzymes essential to mycobacterial survival.</p> <p><strong>Research Focus </strong></p> <p>My lab is focusing on the inhibition of type II NADH-menaquinone dehydrogenase (ndh-2). By inhibiting ndh-2, the electron transport chain in Mtb becomes blocked and shuts down. Ndh-2 is the only NADH dehydrogenase enzyme expressed in Mtb and is thus vital to its survival.<sup>4</sup> Ndh-2 is also found in a number of other bacteria such as Staphylococcus aureus and Enterococcus faecalis but is not expressed in humans.<sup>5</sup> Humans rely only on type I NADH dehydrogenase (ndh-1) and thus minimal toxicity in humans is predicted with ndh-2 inhibitors.</p> </div></div></div> Mon, 14 Aug 2006 23:29:12 +0000 Miguel Mitchell 118 at http://www.thesynapticleap.org Sulfonamides http://www.thesynapticleap.org/node/440 <div class="field field-name-taxonomy-vocabulary-3 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Community&nbsp;</h3> <span class="field-items"> <a href="/malaria/posts">malaria research community</a> </span> </div> <div class="field field-name-taxonomy-vocabulary-4 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Subject&nbsp;</h3> <span class="field-items"> <a href="/taxonomy/term/25">Results</a>, <a href="/resourcesneeded">Request for Help</a>, <a href="/taxonomy/term/16">Miscellaneous</a> </span> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>As I alluded to at the end of my <a href="http://www.thesynapticleap.org/node/420">previous entry</a>, I've been working on a way to make sulfonamides of the arryl pyrrole series for the OSDD Malaria project.</p> <p> <img alt="" src="/files/tsl/images/Sulfonamides.png" /></p> <p>  <br />  <br />  <br />  <br />  <br />  <br /><strong>Figure 1.</strong> Examples of sulfonamides that are currently being made for testing as anti-malarials.</p></div></div></div> Tue, 26 Feb 2013 12:03:15 +0000 Matin 440 at http://www.thesynapticleap.org Biological Results for ATP Series from April 2013 http://www.thesynapticleap.org/node/444 <div class="field field-name-taxonomy-vocabulary-3 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Community&nbsp;</h3> <span class="field-items"> <a href="/malaria/posts">malaria research community</a> </span> </div> <div class="field field-name-taxonomy-vocabulary-4 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Subject&nbsp;</h3> <span class="field-items"> <a href="/taxonomy/term/25">Results</a> </span> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p><strong>Comments on Latest Biological Results - April 2013</strong></p> <p> Data may be viewed <a href="http://malaria.ourexperiment.org/uri/374">here</a>.<br /> General page for the whole aminothienopyrmidine series is <a href="http://openwetware.org/wiki/OSDDMalaria:GSK_Amino-thienopyrimidine_Series">here</a>.</p> <p>The content of this post is also viewable on a <a href="https://plus.google.com/u/0/b/114702323662314783325/114702323662314783325/posts/X7agASD4WV9">Google+ post</a>.</p></div></div></div> Wed, 01 May 2013 03:48:09 +0000 MatTodd 444 at http://www.thesynapticleap.org Biological Data http://www.thesynapticleap.org/node/443 <div class="field field-name-taxonomy-vocabulary-3 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Community&nbsp;</h3> <span class="field-items"> <a href="/malaria/posts">malaria research community</a> </span> </div> <div class="field field-name-taxonomy-vocabulary-4 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Subject&nbsp;</h3> <span class="field-items"> <a href="/taxonomy/term/25">Results</a> </span> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>Chid pages to this one focus on biological evaluation in the <a href="http://openwetware.org/wiki/OSDDMalaria:GSK_Amino-thienopyrimidine_Series">GSK ATP project</a> - results and the response to the results.</p> <p> </p> </div></div></div> Wed, 01 May 2013 03:39:33 +0000 MatTodd 443 at http://www.thesynapticleap.org The GSK Aminothienopyrimidine (ATP) Series http://www.thesynapticleap.org/node/442 <div class="field field-name-taxonomy-vocabulary-3 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Community&nbsp;</h3> <span class="field-items"> <a href="/malaria/posts">malaria research community</a> </span> </div> <div class="field field-name-taxonomy-vocabulary-4 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Subject&nbsp;</h3> <span class="field-items"> <a href="/taxonomy/term/25">Results</a> </span> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p>The second strand of the open source drug discovery for malaria project involves aminothienopyrimidines (ATPs). <a href="http://openwetware.org/wiki/OSDDMalaria:GSK_Amino-thienopyrimidine_Series">The wiki summary page</a> contains the current To Do list. Child pages to this one refer to specific aspects of the project.</p> </div></div></div> Wed, 01 May 2013 03:38:04 +0000 MatTodd 442 at http://www.thesynapticleap.org OSDDMalaria Agenda, Feb 26th 2013 http://www.thesynapticleap.org/node/439 <div class="field field-name-taxonomy-vocabulary-3 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Community&nbsp;</h3> <span class="field-items"> <a href="/malaria/posts">malaria research community</a> </span> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p> </p> <p> </p></div></div></div> Mon, 25 Feb 2013 21:10:24 +0000 Alice Williamson 439 at http://www.thesynapticleap.org Open Source Drug Discovery for Malaria Project Meeting February 26th 2013 http://www.thesynapticleap.org/node/441 <div class="field field-name-taxonomy-vocabulary-3 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Community&nbsp;</h3> <span class="field-items"> <a href="/malaria/posts">malaria research community</a> </span> </div> <div class="field field-name-taxonomy-vocabulary-4 field-type-taxonomy-term-reference field-label-above"> <h3 class="field-label">Subject&nbsp;</h3> <span class="field-items"> <a href="/taxonomy/term/25">Results</a> </span> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p> </p></div></div></div> Thu, 21 Mar 2013 02:53:04 +0000 MatTodd 441 at http://www.thesynapticleap.org