The Synaptic Leap

 Open-source science takes on neglected diseaseDeclan ButlerNature News, (04 Feb 2010)info:doi/10.1038/news.2010.50Chemist launches collaborative project to make more potent form of much-needed drug ... A chemist — and social entrepreneur — in Australia is launching an open-source research project to develop a more potent form of a front-line drug against the debilitating neglected tropical disease schistosomiasis. Matthew Todd of the University of Sydney hopes to persuade research chemists across the world to share laboratory time and expertise in a collaborative effort to find a cheap and efficient synthesis of the drug praziquantel. All results will be published in almost real time on the project's website — free of intellectual property restrictions — and later in journals, with substantial contributors becoming authors on any resulting papers. Todd, who is currently on a six-month sabbatical at Stanford University in California, had been playing with the idea since 2006. He hired a post-doc last month after receiving three-year funding of Aus$400,000 for the project — mostly from the Australian government with Aus$75,000 coming from the World Health Organization — to start putting it into practice.Posted by NatureRevMicrobiol and 1 other to schistosomiasis Schitosoma treatment research chemistry on Sat Feb 06 2010 at 03:41 UTC | info | related

 Sequencing unlocks secrets of blood parasites - on articles in NatureSequencing unlocks secrets of blood parasitesKerri SmithNature News, (15 Jul 2009)info:doi/10.1038/news.2009.692Possible drug targets revealed in flatworms that cause schistosomiasis ... Researchers have sequenced the genomes of two species of flatworm that cause the tropical disease schistosomiasis, revealing potential weaknesses that could be exploited by drug developers. Schistosomiasis — also called bilharzia — is transmitted by water-borne snails, and affects more than 200 million people, many of whom live in Africa. Infections are usually chronic, rather than fatal. There is currently only one drug, praziquantel, in use against schistosomiasis and, although it is effective, scientists don't understand exactly how it works. An international team led by Matthew Berriman at the Wellcome Trust Sanger Institute in Cambridge, UK, and Najib El-Sayed at the University of Maryland in College Park has sequenced the genome of the parasite found throughout Africa (Schistosoma mansoni). The Asian strain (S. japonicum) was tackled by the Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium.Posted by NatureRevMicrobiol to flatworms Schistosoma japonicum schistosomiasis schistosoma Schistosoma mansoni genomes on Thu Jul 16 2009 at 03:35 UTC | info | related

 The NIH-NIAID Schistosomiasis Resource CenterPLoS Neglected Tropical Diseases 2 (7), e267 (2008)info:doi/10.1371/journal.pntd.0000267Posted by Papps to Resource Center schistosomiasis NIH on Thu Sep 11 2008 at 22:29 UTC | info | related

 Comparative evolution of the fluorescent antibodies directed against the larval stages and the adults of Schistosoma mansoni. I. Experimental schistosomiasis in untreated miceT Kien Truong, G Sarasin, and P Ambroise-ThomasAnnals of tropical medicine and parasitology 64 (1), 87-92 (Mar 1970)info:pmid/4922149Posted by gjwilliams2 to schistosomiasis Antibody Formation Larva schistosoma Fluorescent Antibody Technique growth & development female liver pancreas animals pathology mice immunology on Thu Jul 03 2008 at 00:15 UTC | info | related

 Comarative evolution of the fluorescent antibodies directed against the larval stages and the adults of Schistosoma mansoni. II. Experimental schistosomiasis in mice after treatment with niridazoleP Ambroise-Thomas, G Sarasin, and T Kien TruongAnnals of tropical medicine and parasitology 64 (1), 93-9 (Mar 1970)info:pmid/4922150Posted by gjwilliams2 to Anthelmintics Stimulation, Chemical Thiazoles schistosomiasis Antibody Formation schistosoma drug therapy therapeutic use Fluorescent Antibody Technique Imidazoles growth & development female animals mice immunology on Wed Jul 02 2008 at 23:28 UTC | info | related

 Drug repositioning: identifying and developing new uses for existing drugsDRUG REPOSITIONING IDENTIFYING AND DEVELOPING NEW USES FOR EXISTING DRUGSTed Ashburn and Karl ThorNature Reviews Drug Discovery 3 (8), 673-83 (Aug 2004)info:doi/10.1038/nrd1468Posted by Papps and 1 other to piggy-backing NTDs repositioning neglected schisto drugs on Thu Sep 03 2009 at 00:13 UTC | info | related

 Recent initiatives and strategies to developing new drugs for tropical parasitic diseasesExpert Opinion on Drug Discovery 3 (2), 173 (2008)info:doi/10.1517/17460441.3.2.173Posted by Papps to piggy-backing NTDs conor neglected schisto drugs on Thu Sep 03 2009 at 00:12 UTC | info | related

 The genome of the blood fluke Schistosoma mansoniMatthew Berriman et al.Nature 460 (7253), 352-8 (16 Jul 2009)info:doi/10.1038/nature08160Posted by Papps and 1 other to saj schisto pzq sequencing genome nature on Thu Sep 03 2009 at 00:11 UTC | info | related

 Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agentsTetrahedron Letters 50 (15), 1710 (2009)info:doi/10.1016/j.tetlet.2009.01.120Posted by Papps to oxadiazole maloney Williams schisto on Tue Jun 16 2009 at 09:01 UTC | info | related

 Schistosomiasis control: keep taking the tabletsTrends in Parasitology 20 (2), 92 (2004)info:doi/10.1016/j.pt.2003.11.010Posted by Papps to tchuente kusel Hagan appleton tablets Coles schisto review on Tue Jun 16 2009 at 08:45 UTC | info | related

 Helminth infections: the great neglected tropical diseasesPeter J Hotez et al.The Journal of clinical investigation 118 (4), 1311-21 (Apr 2008)info:pmid/18382743 | info:doi/10.1172/JCI34261Posted by Papps and 1 other to hotez schisto Helminth king clinical review on Tue Jun 16 2009 at 08:42 UTC | info | related

 Mefloquine—An Aminoalcohol with Promising Antischistosomal Properties in MicePLoS Neglected Tropical Diseases 3 (1), e350 (2009)info:doi/10.1371/journal.pntd.0000350Posted by Papps to utzinger mefloquine schisto Analog pzq PLoS on Sat Feb 28 2009 at 23:45 UTC | info | related

 Neglected Disease Research and Development: How Much Are We Really Spending?PLoS Medicine 6 (2), e30 (2009)info:doi/10.1371/journal.pmed.1000030Posted by Papps to moran neglected George schisto Daly drugs on Tue Feb 24 2009 at 07:17 UTC | info | related

 Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasisCurrent Opinion in Infectious Diseases 21 (6), 659 (2008)info:doi/10.1097/qco.0b013e328318978fPosted by Papps to Current Opinion donato doenhoff schisto praziquantel pzq review ejocpaper on Wed Jan 21 2009 at 11:45 UTC | info | related

 Two Years after the Fourth External Review: TDR Moves Forward with a New Vision and StrategyPLoS Neglected Tropical Diseases 2 (11), e307 (2008)info:doi/10.1371/journal.pntd.0000307Posted by Papps to piero TDR Agenda schisto WHO review on Mon Dec 08 2008 at 23:23 UTC | info | related

 Acura New And Used Cars Leasing DealsPosted by serg1111213 to annotated schistosomiasis praziquantel schistosoma bibliography on Sun Feb 21 2010 at 12:32 UTC | info | related

 Cadillac New And Used Cars Leasing DealsPosted by serg1111213 to annotated schistosomiasis praziquantel schistosoma bibliography on Sun Feb 21 2010 at 12:30 UTC | info | related

 Lincoln Cars New And Used Cars Leasing DealsPosted by serg1111213 to annotated schistosomiasis praziquantel schistosoma bibliography on Sun Feb 21 2010 at 12:28 UTC | info | related

 Mercedes Benz New And Used Cars Leasing DealsPosted by serg1111213 to annotated schistosomiasis praziquantel schistosoma bibliography on Sun Feb 21 2010 at 12:27 UTC | info | related

 Acura New And Used Cars Leasing OffersPosted by serg1111213 and 1 other to oa.new driade schisto US labs css Bioinformatics GIS on Sun Feb 21 2010 at 12:33 UTC | info | related