The Synaptic Leap

 Estimating the extent of spatial association of Mycobacterium bovis infection in badgers in Ireland.G Kelly, G McGrath, and S MoreEpidemiology and infection 138 (2), 270-9 (Feb 2010)info:pmid/19653926 | info:doi/10.1017/S0950268809990471Posted by WildlifeDiseaseInformationNode to wdin.blogspot.com bacterial diseases badgers Mammals Ireland Tuberculosis Epidemiology on Mon Feb 08 2010 at 21:21 UTC | info | related

 Drug-resistant TB Found In USMichael CasalsHolistic Wellness, (14 Jan 2010)Posted by HolisticGuy to states cdc tb United Drug resistance Tuberculosis on Sun Jan 17 2010 at 01:41 UTC | info | related

 Tuberculosis epidemiology in India: a review.V K ChadhaThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 9 (10), 1072-82 (Oct 2005)info:pmid/16229217Posted by sathish3107 with 1 comment to india Tuberculosis on Sat Jan 16 2010 at 08:38 UTC | info | related

 Haiti Hospital’s Fight Against TB Falls to One Man - NYTimes.comwww.nytimes.comIn normal times, Haiti sees about 30,000 new cases of tuberculosis each year. Among infectious diseases, it is the country’s second most common killer after AIDS, according to the World Health Organization. The situation has gone from bad to worse because the earthquake set off a dangerous diaspora. Most of the sanatorium’s several hundred surviving patients fled and are now living in the densely packed tent cities where experts say they are probably spreading the disease. Most of these patients have also stopped taking their daily regimen of pills, thereby heightening the chance that there will be an outbreak of a strain resistant to treatment, experts say.Posted by NatureRevMicrobiol to haiti tb Tuberculosis on Sat Feb 06 2010 at 02:57 UTC | info | related

 New Vaccine Effective In Preventing TB In HIV-positive Patientswww.medicalnewstoday.comResults from clinical trials conducted in Tanzania show that a new vaccine against tuberculosis, Mycobacterium vaccae (MV), is effective in preventing tuberculosis in people with HIV infection. Findings from the trials, which were conducted by investigators from Dartmouth Medical School in the United States, will be published in the next issue of AIDS, the leading journal in the field of HIV and AIDS research. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals, and institutions in medicine, nursing, allied health, and pharmacy. TB is the most common cause of death associated with HIV/Aids in developing countries, and the results of the Tanzanian trials are a "significant milestone," according to Principal Investigator Ford von Reyn, M.D., director of the DarDar International Programs for the Section on Infectious Disease and International Health at DMS.Posted by NatureRevMicrobiol to tb vaccines Tuberculosis vaccine HIV AIDS on Sun Jan 31 2010 at 00:24 UTC | info | related

 Vaccine to prevent TB in HIV patients - Health - Health & Fitness - Life - The Times of Indiatimesofindia.indiatimes.comDisclosing results of a clinical trial, researchers at Dartmouth Medical School (DMS) have shown that a new vaccine against tuberculosis, Mycobacterium vaccae (MV), is effective in preventing TB in people with HIV infection. The DarDar Health Study, named for Dartmouth and Dar es Salaam, Tanzania, found that MV immunization reduced the rate of definite tuberculosis by 39 percent among 2,000 HIV-infected patients in Tanzania. "Since development of a new vaccine against tuberculosis is a major international health priority, especially for patients with HIV infection, we and our Tanzanian collaborators are very encouraged by the results of the DarDar Study," said Principal Investigator Dr. Ford von Reyn. The 7-year, randomised, placebo-controlled trial was conducted in Tanzania with collaborators at the Muhimbili University of Health and Allied Sciences (MUHAS) in Dar es Salaam, and was supported by a grant from the National Institutes of Health (NIH) in the United States. "The study confirms that University institutions from the northern and southern hemispheres can establish partnerships to perform quality clinical research work with global importance. The results of the study are not only good news for people living in regions with high infection rates of HIV and tuberculosis but has also contributed to capacity building in performing TB vaccine trials among HIV infected persons in Tanzania,” said Dr. Kisali Pallangyo, the senior collaborator at MUHAS.Posted by NatureRevMicrobiol to tb vaccines Tuberculosis vaccine HIV AIDS on Sun Jan 31 2010 at 00:22 UTC | info | related

 BBC News - Vaccine 'could cut HIV TB deaths' - on article in Aidsnews.bbc.co.ukA vaccine could cut tuberculosis cases among HIV-positive Africans by almost two-fifths, a US study suggests. The lung infection is the most common cause of death among HIV patients in the continent. Journal Aids reports that Dartmouth Medical School research involving 2,000 people found significantly fewer TB cases in vaccinated patients. An expert said the jab could be a cheaper option for countries struggling to find money for extra anti-HIV drugs.Posted by NatureRevMicrobiol and 1 other to tb vaccines Tuberculosis vaccine HIV AIDS on Sun Jan 31 2010 at 00:17 UTC | info | related

 Performance of the tuberculin skin test and interferon-gamma release assay for detection of tuberculosis infection in immunocompromised patients in a BCG-vaccinated populationEun Young Kim et al.BMC Infectious Diseases 9 (1), 207 (15 Dec 2009)info:doi/10.1186/1471-2334-9-207Posted by mattprice to diagnostics Tuberculosis on Wed Dec 23 2009 at 22:39 UTC | info | related

 BBC News - Haiti children face ongoing disease and traumanews.bbc.co.ukSome of the most harrowing stories coming out of the devastation in Haiti are those of children, alone, scared and severely injured. Under-18s make up almost half of Haiti's 10-million population and aid agencies are warning they are at great risk from ongoing physical and psychological trauma. Already the country faces the highest rates of infant and child mortality in the Western hemisphere with diarrhoea, respiratory infections, tuberculosis among the leading causes of death. It is also estimated there are 19,000 children with HIV/Aids with few drugs available to treat them. Unicef, which suffered heavy damage to its own offices in Port-au-Prince, says children are "tremendously vulnerable". Gareth Owen, Save the Children's director of emergencies, said petrified children were sleeping amongst dead bodies and were in grave danger. He estimates up to two million children could be affected by the disaster.Posted by NatureRevMicrobiol to haiti diarrhea tb infectious diseases Tuberculosis HIV AIDS children on Sun Jan 17 2010 at 17:15 UTC | info | related

 Audi New And Used Cars Leasing OffersAudi New And Used Cars Leasing OffersPosted by serg1111212 (who is an author) with 1 comment to pzq protease Tuberculosis CI OpenURL malaria on Sat Jan 09 2010 at 11:59 UTC | info | related

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 Familial tuberculosis mimicking advanced ovarian c... [Infect Dis Obstet Gynecol. 2009] - PubMed resultwww.ncbi.nlm.nih.govPosted by Esm to Tuberculosis on Fri Jan 08 2010 at 12:09 UTC | info | related

Tuberculosis (Edinburgh, Scotland) (31 December 2009)

Due to the complexity of the immune response to a Mycobacterium tuberculosis infection, identifying new, effective therapies and vaccines to combat it has been a problematic issue. Although many advances have been made in understanding particular mechanisms involved, they have, to date, proved insufficient to provide real breakthroughs in this area of tuberculosis research. The term "Translational Systems Biology" has been formally proposed to describe the use of experimental findings combined with mathematical modeling and/or engineering principles to understand complex biological processes in an integrative fashion for the purpose of enhancing clinical practice. This opinion piece discusses the importance of using a Translational Systems Biology approach for tuberculosis research as a means by which to go forward with the potential for significant breakthroughs to occur.
Judy Day, Larry Schlesinger, Avner Friedman

 NGC - NGC Summarywww.guideline.govPosted by amilmon1 to Tuberculosis on Mon Jan 04 2010 at 19:37 UTC | info | related

 NGC - NGC Summarywww.guideline.govPosted by amilmon1 to Tuberculosis on Mon Jan 04 2010 at 19:37 UTC | info | related

 Researchers Identify Tuberculosis Strain That Thrives on Antibiotic - on article in Int J Tuberculosis Lung Diseasewww.jhsph.eduScientists have identified a strain of antibiotic-resistant tuberculosis that thrives in the presence of rifampin, a front-line drug in the treatment of tuberculosis. The bacterium was identified in a patient in China and is described in a study by researchers at the Johns Hopkins Bloomberg School of Public Health, Chongqing Pulmonary Hospital, Lanzhou University and Fudan University. The researchers determined that the bacteria grew poorly in the absence of the antibiotic rifampin and better in the presence of the drug. They also observed that the patient’s condition grew worse with treatment regimens containing rifampin, before being cured with rifampin-free regimens. The study, which will appear in the January 2010 issue of The International Journal of Tuberculosis and Lung Disease, is among the first to document the treatment of a patient with rifampin-dependent infection.Posted by NatureRevMicrobiol to antibiotic resistance Tuberculosis tb on Sat Jan 02 2010 at 01:26 UTC | info | related

 First Case of Highly Drug-Resistant TB Found in US - ABC Newsabcnews.go.comIt started with a cough, an autumn hack that refused to go away. Then came the fevers. They bathed and chilled the skinny frame of Oswaldo Juarez, a 19-year-old Peruvian visiting to study English. His lungs clattered, his chest tightened and he ached with every gasp. During a wheezing fit at 4 a.m., Juarez felt a warm knot rise from his throat. He ran to the bathroom sink and spewed a mouthful of blood. I'm dying, he told himself, "because when you cough blood, it's something really bad." It was really bad, and not just for him. Doctors say Juarez's incessant hack was a sign of what they have both dreaded and expected for years — this country's first case of a contagious, aggressive, especially drug-resistant form of tuberculosis. The Associated Press learned of his case, which until now has not been made public, as part of a six-month look at the soaring global challenge of drug resistance.Posted by NatureRevMicrobiol to XDR Drug resistance antibiotic resistance tb Tuberculosis on Sat Jan 02 2010 at 00:42 UTC | info | related

 First case of highly drug-resistant TB found in US - washingtonpost.comwww.washingtonpost.comJuarez's strain - so-called extremely drug-resistant (XXDR) TB - has never before been seen in the U.S., according to Dr. David Ashkin, one of the nation's leading experts on tuberculosis. XXDR tuberculosis is so rare that only a handful of other people in the world are thought to have had it. "He is really the future," Ashkin said. "This is the new class that people are not really talking too much about. These are the ones we really fear because I'm not sure how we treat them." Forty years ago, the world thought it had conquered TB and any number of other diseases through the new wonder drugs: Antibiotics. U.S. Surgeon General William H. Stewart announced it was "time to close the book on infectious diseases and declare the war against pestilence won." Today, all the leading killer infectious diseases on the planet - TB, malaria and HIV among them - are mutating at an alarming rate, hitchhiking their way in and out of countries. The reason: Overuse and misuse of the very drugs that were supposed to save us.Posted by NatureRevMicrobiol to XDR Drug resistance antibiotic resistance tb Tuberculosis on Sat Jan 02 2010 at 00:38 UTC | info | related

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