The Synaptic Leap

 An algorithm for tuberculosis screening and diagnosis in people with HIVKevin P. Cain et al.The New England Journal of Medicine 362 (8), 707-16 (25 Feb 2010)info:pmid/20181972 | info:doi/10.1056/NEJMoa0907488Posted by EBJournals and 2 others to wb-1Mar2010 From 25Feb2010 to 3Mar2010 EB Journals ebm methods Tuberculosis blood diagnosis therapy on Mon Mar 08 2010 at 13:41 UTC | info | related

 Timing of initiation of antiretroviral drugs during tuberculosis therapySalim S. Abdool Karim et al.The New England Journal of Medicine 362 (8), 697-706 (25 Feb 2010)info:pmid/20181971 | info:doi/10.1056/NEJMoa0905848Posted by EBJournals and 2 others to wb-1Mar2010 From 25Feb2010 to 3Mar2010 EB Journals ebm South Africa methods Africa Mortality Tuberculosis diagnosis therapy on Mon Mar 08 2010 at 13:41 UTC | info | related

 Intracerebral Mycobacterium bovis bacilli Calmette-Guerin infection-induced immune responses in the CNSIntracerebral Mycobacterium bovis bacilli CalmetteGuerin infectioninduced immune responses in the CNS☆Journal of Neuroimmunology 213 (1-2), 112 (2009)info:doi/10.1016/j.jneuroim.2009.05.008Times Cited: 0Posted by rjoy to T(H)17 CELLS HUMAN MICROGLIA EFFECTOR FUNCTIONS Dendritic cells and microglia Mycobacterial infection REGULATORY T-CELLS TUMOR-NECROSIS-FACTOR Factor-Alpha BCG IL-17 Central-Nervous-System dendritic cells regulatory T cells CNS Tuberculosis IFN-gamma on Wed Mar 03 2010 at 00:40 UTC | info | related

 One-plasmid tunable coexpression for mycobacterial protein-protein interaction studiesOneplasmid tunable Coexpression for mycobacterial proteinprotein interaction studiesYong Chang et al.Protein science : a publication of the Protein Society 18 (11), 2316 (16 Sep 2009)info:pmid/19760663 | info:doi/10.1002/pro.242Times Cited: 0Posted by rjoy and 1 other to 2-HYBRID SYSTEM stearoyl-CoA Delta(9) desaturase complex red fluorescence inducible protein mycobacterium expression system tunable coexpression smegmatis ESCHERICHIA-COLI identification purification Reporter expression Tuberculosis gene yeast on Wed Mar 03 2010 at 00:40 UTC | info | related

 The duration of the effects of repeated widespread badger culling on cattle tuberculosis following the cessation of culling.Helen Jenkins, Rosie Woodroffe, and Christl DonnellyPloS one 5 (2), e9090 (2010)info:pmid/20161769 | info:doi/10.1371/journal.pone.0009090Posted by WildlifeDiseaseInformationNode to domestic animals wdin.blogspot.com bacterial diseases culling badgers Mammals United Kingdom Tuberculosis on Thu Feb 25 2010 at 22:47 UTC | info | related

 Treatment of multidrug-resistant tuberculosisM D IsemanThe New England journal of medicine 329 (11), 784-91 (09 Sep 1993)info:pmid/8350889Posted by vircasti and 1 other to Antitubercular Agents Drug Therapy, Combination Drug Resistance, Microbial AIDS-Related Opportunistic Infections drug monitoring Mycobacterium tuberculosis Treatment Outcome humans Tuberculosis on Thu Feb 25 2010 at 22:45 UTC | info | related

 Tuberculosis Medicationwww.bestonhealth.comBest on Health provides tuberculosis treatment related information including symptoms and risk factors.Tuberculosis is completely curable by administering anti-tuberculosis therapyPosted by shaileshsmith to Medication Tuberculosis on Wed Mar 10 2010 at 11:23 UTC | info | related

 Buy Ethambutol Online - No Prescription Needed - Cheapest Priceswww.olark.comMyambutol is an antibacterial drug and a bacteriostatic drug. It's generic name is Ethambutol. It is used to treat tuberculosis & used in almost all the combinations of drugs to treat TB.Posted by DeniseMeds to Myambutol bacteriostatic ethambutol Tuberculosis antibacterial on Wed Mar 10 2010 at 11:16 UTC | info | related

 The changing pattern of tuberculosis and HIV co-infection in immigrants and Spaniards in the last 20 yearsM Velasco et al.HIV medicine 9 (4), 227-33 (Apr 2008)info:pmid/18366446 | info:doi/10.1111/j.1468-1293.2008.00550.xPosted by vircasti to Emigrants and Immigrants CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Americas morbidity European Continental Ancestry Group HIV Infections Prospective Studies Spain risk factors female humans incidence Male Africa Tuberculosis adult Asia europe on Thu Feb 25 2010 at 22:45 UTC | info | related

 Timing of Initiation of Antiretroviral Drugs during Tuberculosis TherapyTiming of initiation of antiretroviral drugs during tuberculosis therapySalim S. Abdool Karim et al.The New England Journal of Medicine 362 (8), 697-706 (25 Feb 2010)info:pmid/20181971 | info:doi/10.1056/NEJMoa0905848Posted by mattprice and 2 others to Tuberculosis HIV on Thu Feb 25 2010 at 07:26 UTC | info | related

 An Algorithm for Tuberculosis Screening and Diagnosis in People with HIVKevin P. Cain et al.The New England Journal of Medicine 362 (8), 707-16 (25 Feb 2010)info:doi/10.1056/NEJMoa0907488Posted by boylucas and 1 other to diagnóstico VIH Tuberculosis screening on Thu Feb 25 2010 at 04:52 UTC | info | related

 Cell - Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosiswww.cell.comWe performed a genome-wide siRNA screen to identify host factors that regulated pathogen load in human macrophages infected with a virulent strain of Mycobacterium tuberculosis. Iterative rounds of confirmation, followed by validation, identified 275 such molecules that were all found to functionally associate with each other through a dense network of interactions. This network then yielded to a molecular description of the host cell functional modules that were both engaged and perturbed by the pathogen. Importantly, a subscreen against a panel of field isolates revealed that the molecular composition of the host interface varied with both genotype and the phenotypic properties of the pathogen. An analysis of these differences, however, permitted identification of those host factors that were invariantly involved, regardless of the diversification in adaptive mechanisms employed by the pathogen. Interestingly, these factors were found to predominantly function through the regulation of autophagy.Posted by NatureRevMicrobiol to tb Tuberculosis Autophagy siRNA innate immunity cell biology on Mon Mar 08 2010 at 04:17 UTC | info | related

 Cell - TB: Screening for Responses to a Vile Visitorwww.cell.comMycobacteria, the pathogens that cause tuberculosis and leprosy, establish long-term infections in host macrophages. Recent studies, including two genetic screens reported in this issue of Cell (Kumar et al., 2010; Tobin et al., 2010,Kumar et al., 2010; Tobin et al., 2010), reveal that virulent mycobacteria evade the host immune system by stimulating production of anti-inflammatory molecules and inhibiting autophagy.Posted by NatureRevMicrobiol to mycobacteria tb Tuberculosis Autophagy inflammation innate immunity on Mon Mar 08 2010 at 04:15 UTC | info | related

Tuberculosis (Edinburgh, Scotland), Vol. 87, No. 4. (July 2007), pp. 384-390.

The control of ammonia assimilation in Mycobacterium tuberculosis is poorly understood. We have been investigating a regulatory cascade predicted to control the activity of glutamine synthetase (GS). We previously demonstrated that the GS-modifying protein, GlnE (an adenylyl transferase), is essential for M. tuberculosis growth. GlnD, a uridylyl transferase, is involved in the control of GlnE activity in other bacteria. In M. tuberculosis, glnD is arranged in an apparent operon with amt and glnB; all three genes are up-regulated in a low-ammonia medium. We constructed an in-frame deletion of glnD by homologous recombination. The mutant had no growth defect in media containing different nitrogen sources. Total GS activity in culture filtrates was markedly reduced in the mutant, although activity in cell-free extracts remained normal. Virulence was unaffected in both in vitro and in vivo model systems of infection, indicating that the presence of extra-cellular GS is not critical for virulence and that the residual intra-cellular GS activity is sufficient. Thus although GlnD does play a role in the control of ammonia assimilation, it is not required for virulence.
Rose Read, Carey Pashley, Debbie Smith, Tanya Parish

 Adding moxifloxacin is associated with a shorter time to culture conversion in pulmonary tuberculosis et al.Posted by mattprice to Tuberculosis on Sun Feb 21 2010 at 13:22 UTC | info | related

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 Tuberculosis and air travel: a systematic review and analysis of policy : The Lancet Infectious Diseaseswww.thelancet.comWHO international guidelines for the control of tuberculosis in relation to air travel require—after a risk assessment—tracing of passengers who sat for longer than 8 h in rows adjacent to people with pulmonary tuberculosis who are smear positive or smear negative. A further recommendation is that all commercial air travel should be prohibited until the person has two consecutive negative sputum smears for drug-susceptible tuberculosis or two consecutive cultures for multidrug-resistant tuberculosis. In this Review I examine the evidence put forward to support these recommendations and assess whether such an approach is justifiable. A systematic review identified 39 studies of which 13 were included. The majority of studies found no evidence of transmission. Only two studies reported reliable evidence of transmission. The analysis suggests that there is reason to doubt the value of actively screening air passengers for infection with Mycobacterium tuberculosis and that the resources used might be better spent addressing other priorities for the control of tuberculosis.Posted by NatureRevMicrobiol to airplanes travel Tuberculosis tb on Mon Feb 22 2010 at 19:01 UTC | info | related