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Primary tabs

1. Personal Information

Name
Bart Staker

3. Publications

Publications

1: Marchand C, Antony S, Kohn KW, Cushman M, Ioanoviciu A, Staker BL, Burgin
AB, Stewart L, Pommier Y.
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor
paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.
Mol Cancer Ther. 2006 Feb;5(2):287-95.
PMID: 16505102 [PubMed - indexed for MEDLINE]

2: Ioanoviciu A, Antony S, Pommier Y, Staker BL, Stewart L, Cushman M.
Synthesis and mechanism of action studies of a series of norindenoisoquinoline
topoisomerase I poisons reveal an inhibitor with a flipped orientation in the
ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic
analysis.
J Med Chem. 2005 Jul 28;48(15):4803-14.
PMID: 16033260 [PubMed - indexed for MEDLINE]

3: Raymond AC, Staker BL, Burgin AB Jr.
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1).
J Biol Chem. 2005 Jun 10;280(23):22029-35. Epub 2005 Apr 4.
PMID: 15811850 [PubMed - indexed for MEDLINE]

4: Staker BL, Feese MD, Cushman M, Pommier Y, Zembower D, Stewart L, Burgin AB.

Structures of three classes of anticancer agents bound to the human
topoisomerase I-DNA covalent complex.
J Med Chem. 2005 Apr 7;48(7):2336-45.
PMID: 15801827 [PubMed - indexed for MEDLINE]

5: Hager J, Staker BL, Jakob U.
Substrate binding analysis of the 23S rRNA methyltransferase RrmJ.
J Bacteriol. 2004 Oct;186(19):6634-42.
PMID: 15375145 [PubMed - indexed for MEDLINE]

6: Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L,
Redinbo MR.
Mechanisms of camptothecin resistance by human topoisomerase I mutations.
J Mol Biol. 2004 Jun 11;339(4):773-84.
PMID: 15165849 [PubMed - indexed for MEDLINE]

7: Raymond AC, Rideout MC, Staker B, Hjerrild K, Burgin AB Jr.
Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues.
J Mol Biol. 2004 May 14;338(5):895-906.
PMID: 15111055 [PubMed - indexed for MEDLINE]

8: Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M,
Williams D, Dales NA, Patane MA, Pantoliano MW.
ACE2 X-ray structures reveal a large hinge-bending motion important for
inhibitor binding and catalysis.
J Biol Chem. 2004 Apr 23;279(17):17996-8007. Epub 2004 Jan 30.
PMID: 14754895 [PubMed - indexed for MEDLINE]

9: Fox BM, Xiao X, Antony S, Kohlhagen G, Pommier Y, Staker BL, Stewart L,
Cushman M.
Design, synthesis, and biological evaluation of cytotoxic
11-alkenylindenoisoquinoline topoisomerase I inhibitors and
indenoisoquinoline-camptothecin hybrids.
J Med Chem. 2003 Jul 17;46(15):3275-82.
PMID: 12852757 [PubMed - indexed for MEDLINE]

10: Staker BL, Hjerrild K, Feese MD, Behnke CA, Burgin AB Jr, Stewart L.
The mechanism of topoisomerase I poisoning by a camptothecin analog.
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15387-92. Epub 2002 Nov 8.
PMID: 12426403 [PubMed - indexed for MEDLINE]

11: Hager J, Staker BL, Bugl H, Jakob U.
Active site in RrmJ, a heat shock-induced methyltransferase.
J Biol Chem. 2002 Nov 1;277(44):41978-86. Epub 2002 Aug 13.
PMID: 12181314 [PubMed - indexed for MEDLINE]

12: Bugl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC,
Jakob U.
RNA methylation under heat shock control.
Mol Cell. 2000 Aug;6(2):349-60.
PMID: 10983982 [PubMed - indexed for MEDLINE]

13: Staker BL, Korber P, Bardwell JC, Saper MA.
Structure of Hsp15 reveals a novel RNA-binding motif.
EMBO J. 2000 Feb 15;19(4):749-57.
PMID: 10675344 [PubMed - indexed for MEDLINE]

14: Koh WJ, Stelzer KJ, Peterson LM, Staker BL, Ward WF, Russell KJ, Griffin
TW.
Effect of pentoxifylline on radiation-induced lung and skin toxicity in rats.
Int J Radiat Oncol Biol Phys. 1995 Jan 1;31(1):71-7.
PMID: 7995770 [PubMed - indexed for MEDLINE]

15: Staker BL, Graham MM, Evans ML.
Effect of bicarbonate on stability of the gallium-transferrin complex.
J Nucl Med. 1991 Jul;32(7):1439-41.
PMID: 2066803 [PubMed - indexed for MEDLINE]

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