The Synaptic Leap

The development of a low-cost enantioselective synthesis of PZQ is an open source project, meaning contributors can change anything they wish on these pages. If you wish to contribute, please don't leave comments here. Instead, go to the pages described below and either edit the pages to insert information or leave comments. You can also ask general questions on the Friendfeed page. Please avoid emails if at all possible. 
 
Current help is needed from you (the community) with the following in schisto projects.
 
1) Help obtaining prices for bulk starting materials for racemic PZQ syntheses. This really needs input from industrial chemists who know of suppliers of these materials for low prices.
 
2) Advice on how to increase the yield of, or otherwise improve the procedure employed for, the synthesis of acid chlorides - in our case the synthesis of cyclohexanoyl chloride. 
 
3) As a result of Michael's spectacular success with the cleavage of the amide in PZQ to give praziquanamine, we need suggestions on how to resolve praziquanamine - i.e. which chiral acid should we look at, and what sorts of reaction conditions?