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Reissert Approach to rac-PZQ
Communityschisto research community
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The most obvious, and known, approach to rac-PZQ is using Reissert chemistry.
This approach has been used in the following publications:
 Organic Sonochemistry. Synthesis and Use of Reissert compounds under PTC-Ultrasound, J. Ezquerra and J. Alvarez-Builla, J. Heterocyclic Chem. 1988, 25, 917-925.
 Alkylation of isoquinolines via 2-benzoyl-1,2-dihydroisoquinaldonitriles: 1-Benzylisoquinoline, B. C. Uff, J. R. Kershaw and J. L. Neumeyer, Org. Synth. 1988, 6, 115; Org. Synth. 1977, 56, 19.
Child pages from this one detail attempts at this synthesis, and can host comment about it.